The worms recover if placed in a piperazine free medium. It causes hyperpolarization of muscle by its GABA agonistic action opening Cl - channels that causes relaxation and depresses responsiveness to contractile action of acetylcholine thereby flaccid paralysis occurs. The reference standard drug used in this experiment is piperazine citrate. Accordingly, this prompted us to investigate the anthelmintic activity of Tamarindus indica bark extracts in comparison to the leaf extract. but the anthelmintic activity of the bark extracts of Tamarindus indica has not been evaluated. The anthelmintic activity of leaves has been reported by Sampat et al. Tamarindus indica is a tree belonging to the family Caesalpiniaceae whose different parts are used as traditional medicine as analgesic, antiinflammatory, diuretic, febrifuge, and anthelmintic, antifungal and in gastrointestinal problems. Helminthiasis is rarely fatal, but is a major cause of morbidity. They harm the host by depriving him of food, causing blood loss, injury to organs, intestinal or lymphatic obstruction and by secreting toxins. Anthelmintics are drugs that either kill or expel infesting helminths and the gastrointestinal tract is the abode of many helminths, although some also live in tissues, or their larvae migrate into tissues. In developing countries they pose a major threat to public health and contribute to the prevalence of malnutrition, anemia, eosinophilia, and pneumonia. Helminth infections are among the commonest infections in man, affecting a large proportion of the world's population.
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